Caloramator sp. Tolerance of Pretreatment Inhibitors from Lignocellulosics

Stage: Development
ORNL inventors discovered a novel microorganism that displays exceptional tolerance to several growth inhibitors generated during dilute acid pretreatment of lignocellulosic biomass.

Vanillin, furfural, hydroxymethylfurfural and lignin are known to inhibit the growth of microorganisms, such as yeast, during fermentation of sugars to alcohols. The new, isolated organism can be used as a source of resistance factors which could then be engineered into advanced biocatalysts for consolidated bioprocessing of biomass into fuels.

Applications and Industries

• Biofuel production
• Chemical production


• Tolerant to inhibitors vanillin, furfural, and hydroxymethylfurfural